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D’Or Institute for Research and Education - IDOR
Intellectual capital highlights
GRI 3-3
EW MOLECULAR PATHOLOGY
BRL 80 million invested in facilities and equipment
ARTICLES PUBLISHED IN 2023, leading
324 citations
million, in partnership agreements through Open D’Or
FIELDS
Research line covering
We are the main sponsors of D’Or Institute for Research and Education (Instituto D’Or de Pesquisa e Ensino - IDOR, in Portuguese), a non-profit organization that contributes to the advancement of science, aiming to improve human life conditions. As such, the Institute brings together a body of researchers from different backgrounds to develop cutting-edge research and new technologies in the healthcare field.
Since its foundation in 2010, IDOR has been consistently contributing to national and international public health—such as in understanding the role of the Zika virus in nervous system malformation and in research aimed at fighting the Covid-19 pandemic, conducting drug clinical trials and monitoring volunteers (over 6,000 in total) for the Oxford/AstraZeneca study in Brazil and subsequently for the Coronavac/Butantan and Clover vaccines. In addition to its headquarters in Botafogo, the Institute boasts extensive facilities within Hospital Glória D’Or, dedicated to clinical research and educational purposes. It also has units in São Paulo (SP), Salvador (BA) and Brasília (DF), which operate together in research, education and innovation. IDOR extends its research to other Brazilian capitals, benefiting from Rede D’Or’s structure in this process.
International Collaborations
in scientific publications
Publications
Citations
Collaboration in
Countries
International partnerships with the highest number of publications: Monash University (Australia), King’s College (England), Oxford (England), Harvard (United States) and the National Institute of Health and Medical Research - Inserm (France).
*IDOR figures since 2010.
Production and research
GRI 203-2
The outstanding research conducted at IDOR has resulted in around two thousand publications since 2010, which have received over 39,000 citations in highly prestigious scientific journals. During this same period, we have established international scientific partnerships in over 80 countries. Among the studies published, 160 were dedicated to Covid-19 between 2020 and 2023. These figures underscore the strong dedication to science that we uphold at IDOR. In 2023 alone, scientists at IDOR published 192 new articles, resulting in 324 citations. The increasing number of impactful publications is matter of pride for everyone involved.
| 2023 | 2022 | |
|---|---|---|
| Number of articles published | 192 | 236 |
| Number of citations | 324 | 299 |
| Number or researchers | 123 | +100 |
IDOR’s main scientific achievements have been the result of partnerships with important research institutions. In Brazil, key collaborations include cooperative projects with Fiocruz, Federal University of Rio de Janeiro (UFRJ), Federal University of São Paulo (Unifesp), Federal University of Bahia (UFBA) and the University of São Paulo (USP), and internationally, we have forged partnerships with Stanford, University of California, Los Angeles (UCLA) and UC Berkeley.
Neuroscientific research, the cornerstone of IDOR’s operations since its inception, continues to be the Institute’s primary highlight, followed by studies in intensive care. However, other areas such as pediatrics, oncology, cardiology, pathology and hematology have also gained importance over the past years. Currently, our lines of research encompass 12 areas of study.
For instance, at the IDOR’s Center for Applied Neuropsychology (CNA, in Portuguese), a team of specialists in neurology, psychiatry, speech therapy, radiology, psychology and occupational therapy provides specialized multi-professional assistance to children and adolescents with learning disabilities, as well as adults and the elderly with memory challenges or signs of dementia.
IDOR operates through four platforms - structured areas designed to support research and business development -which have undergone a significant infrastructure upgrade this year:
Image acquisition and processing platform
Equipped with state-of-the-art equipment for image acquisition and processing, diagnosis and patient segmentation, fully integrated into our structure for shared analyses.
Translational platform
Cutting-edge technological resources for biochemical and molecular analyses and cellular development. These resources are allocated to research projects focused on the identification of diagnostic or prognostic biomarkers for diseases, especially in oncology, neurology and cardiology. This platform also provides support to areas involved in the development of cellular therapies.
Neuromodulation platform
Consisting of non-invasive brain stimulation equipment used in clinical research in neurology and psychiatry, as well as for clinical rehabilitation.
Clinical research platform
Conducts nationwide clinical trials, both independently and in partnership with the pharmaceutical industry.
Innovation
GRI 3-3
Another pillar of the Institute’s activity is innovation in the healthcare sector, with the promotion of Research, Development and Innovation (RD&I) projects as a strategic goal. As recognition of its expertise in medical biotechnology, IDOR has been accredited as an Embrapii Unit (Brazilian Company for Industrial Research and Innovation) IDOR Medical Biotechnology since 2022. This enables the Institute to co-develop RD&I projects with the industry in the following sublines:
- Pre-clinical trials with advanced methods: includes RD&I projects involving advanced biological models, such as cellular models derived from induced pluripotent stem cells (iPSCs);
- Development of products, processes and medical biotechnology therapies: the priority theme is molecular and cellular biology applied to products, processes and therapies - such as biopharmaceuticals, vaccines, monoclonal antibodies, nucleic acid (DNA and RNA) products, diagnostic kits and advanced therapy products;
- Phase I clinical trials: studies for the assessment of safety and tolerability of therapies and drugs for human use.
The collaboration between IDOR and Embrapii, along with the continued support of this collaboration, confirms the technological and scientific capabilities of the Institute, while also encouraging new partnerships in open innovation.
In its innovation process, IDOR is supported by Open Open D’Or an agency that conducts market studies, identifies innovation opportunities, supports attracting public and private investments, negotiates partnerships, manages RD&I projects, manages intellectual property assets and promotes scientific entrepreneurship. Additionally, it is actively involved in fostering a culture of innovation through the IDOR Science, Technology and Innovation Conference, internal training sessions and policies to stimulate innovation.
| 2023 | 2022 | |
|---|---|---|
| Innovation calls for proposals | ||
| Number of proposals submitted | 4 | 4 |
| Partnerships | ||
| Number of potential partners mapped | 2,142 | 1,801 |
| Number of contracts signed | 45 | 25 |
| Number of technical visits | 3 | 8 |
| Number of prospecting activities | 25 | 19 |
| Amount contracted in Partnership Agreements (BRL) | 629,101 | 0 |
| Results | ||
| Number of products under development | 10 | 11 |
| Intellectual property | ||
| Number of patent application filings | 1 | 1 |
Potential partners mapped
Molecular Pathology Laboratory
With an investment of BRL 80 million in state-of-the-art facilities and equipment, the new Molecular Pathology Laboratory was inaugurated in August 2023, offering unprecedented procedures in Brazil, such as clonality testing and Minimal Residual Disease (MRD) testing, providing a more agile and precise diagnosis in various situations. Results that used to take up to 45 days to be obtained, as samples had to be sent abroad, can now be obtained within a few days through internal laboratory testing.
In oncology, molecular analysis of tumors serves as the cornerstone of personalized medicine, enabling the selection of targeted treatments for identified driver mutations, often leading to better responses with fewer adverse effects. The unit, located in São Paulo (SP), is equipped to serve our 73 hospitals and 55 oncology clinics.
At IDOR, Pathology is a prominent research area, focusing on identifying biomarkers to predicting both the progression potential of diseases and their response to possible treatments.
Key research departments of the IDOR/Rede D’Or Molecular Pathology Laboratory:
- Molecular panels for detecting variants of tumor genetic material (DNA and RNA);
- Liquid biopsy panels to identify genetic material from tumors in the circulation;
- Methylation panels for recognizing epigenetic changes in cancer;
- Spatial biology analyses, which combine the morphological analysis of the tumor tissue with the molecular profile of the cancer to characterize the different cell populations that form the tumor;
- Transcriptome and RNAseq analysis. The platform also supports areas involved in the development of cell therapies.
College of Medical Sciences
GRI 203-2
In addition to collaboration in research, the Institute also contributes to the training and development of physicians and various other healthcare professionals, coordinating over 60 Medical Residency programs and four Multiprofessional Residencies across Rede D’Or hospitals. Furthermore, the institute runs the IDOR College of Medical Sciences, offering various levels of education, starting from undergraduate studies and extending through postgraduate and doctoral programs. IDOR is responsible for coordinating dozens of continuing medical education initiatives within Rede D’Or, such as congresses, symposiums and other events, directly impacting over 20,000 healthcare professionals nationwide each year.
Established in 2017, the IDOR School has already trained 6,500 professionals over the years, with 1,300 trained in 2023 alone. This year, the School received the Social Responsibility certification from the Brazilian Association of Sponsors of Higher Education Institutions (Abmes, in Portuguese), a recognition granted to institutions committed to promoting sustainable development initiatives and well-being in their community.
The first undergraduate program offered by IDOR was Radiology Technology, starting in 2019, to meet the demand for skilled technicians working in the field. Its first class graduated in 2022, the same year it began offering the Nursing undergraduate program validated by the Brazilian Ministry of Education and Culture¹ (MEC, in Portuguese). Students of the School will undertake internships from the early semesters of their undergraduate studies, ensuring that theoretical learning and practical experience go hand in hand. As part of this initiative, the 1st Health Fair was organized to raise awareness of skin cancer prevention, healthy child nutrition and the importance of physical activity. As of 2023, the IDOR School has also introduced the Psychology program.
The inauguration of a new unit in the Glória neighborhood, Rio de Janeiro, marks the beginning of a new era of academic excellence for the institution. This is a modern, inspiring space designed to meet the academic and technological needs of students and faculty alike. It features well-equipped classrooms, communal areas and green spaces, creating an environment conducive to both learning and personal development.
IDOR College trained
PROFISSIONALS
in 2023
Opening of a
NEW UNIT
in the Glória neighborhood, in Rio de Janeiro
1New nurses will undergo a four -year training program grounded in three pillars: care, research, and leadership.
Stimulating science in schools
Aiming to provide a broad and practical insight into career possibilities in the healthcare field, the IDOR Day: Health Careers Immersion was held in September, targeting high school students and their guardians. The event featured a lecture by neuroscientist Stevens Rehen and neuroscience and behavior workshops, first aid, a mini microscopy laboratory, space biology, entrepreneurship and innovation.
Psychology Undergraduate Program
The course was built upon an innovative learning model, centered around a proactive, creative, humanistic, critical and analytical view of the world and professional activities. Throughout the course, students have the opportunity to interact with neuroscience researchers who are leaders in their respective fields of study and to undertake internships with experienced professionals in patient care.
The IDOR School closely collaborates with the IDOR Neuroscience Research Center and the CNA. In addition to guaranteed internship placements, another distinctive feature of the course is the in-depth study of Hospital Psychology, which prioritizes the training of professionals in hospitals and emergency rooms, and Psychology and Clinical Processes, aimed at promoting the health of individuals and groups through educational, preventive and interventional approaches.
Education at IDOR
| IDOR Education in numbers | 2023 | 2022 |
|---|---|---|
| Doctoral programs | 1 | 1 |
| Graduate programs (classes) | 13 | 3 |
| Extension courses | 13 | 10 |
| Undergraduate programs | 3 | 2 |
| Academic Internship Programs in Medicine | 6 | 3 |
| Medical Residency Programs | 64 | 46 |
| Academic Internship Programs in Pharmacy | 1 | * |
| Multiprofessional Residency Programs | 4 | 2 |
| Healthcare professionals trained | 1300 | 935 |
*Planned for 2022, but the class only started in 2023.
